Vaccine is a biological preparation to give acquired immunity against a specific micro-organism to prevent specific bacterial or viral infectious disease. It is basically, weakened or killed formed of specific micro-organism that boost immunity to prevent infection of such types of micro-organism in future. Vaccine can be prophylactic or therapeutic Prophylactic vaccine is to prevent microbes in future infection and therapeutic vaccine is to kill microbes after infection until it reach in severe condition. The administration of vaccine is called vaccination. Influenza vaccine, HPV vaccine and Hepatitis vaccine is the most effective vaccine as known. Sometimes, the normal immune system may not active properly due to some factors like diabetes, HIV infection, existing no strain of B cell in immune system that produces antibodies that usually binds with antigen that is associated with pathogen.